Research Library

Formaldehyde research carried out by formacare

Formacare has carried out extensive research into the benefits, health impact and safety of formaldehyde, below is a list of the studies formacare has participated in or contributed to.

• Arts JHE, Rennen MAJ, de Heer C (2006) Inhaled formaldehyde: Evaluation of sensory irritation in relation to carcinogenicity. Reg. Toxicol. Pharmacol. 44: 144-160
• Arts JHE, Muijser H, Kuper F, Woutersen RA (2008) Setting an indoor air exposure limit for formaldehyde: Factors of concern. Reg. Toxicol. Pharmacol. 52: 189-194
• Kuper CF, van Oostrum L, Ma-Hock L, Durrer S, Woutersen RA (2011) Hyperplasia of the lymphoepithelium of NALT in rats but not in mice upon 28-day exposure to 15 ppm formaldehyde vapor. Exp. Toxicol. Pathol. 63: 25-32
• Lang I, Bruckner T, Triebig G (2008) Formaldehyde and chemosensory irritation in humans: A controlled human exposure study. Reg.Toxicol. Pharmacol. 50: 23-36
• Lu K, Moeller B, Doyle-Eisele M, McDonald J, Swenberg JA (2011) Molecular dosimetry of N²-hydroxymethyl-dG DNA adducts in rats exposed to formaldehyde. Chem. Res. Toxicol. 24: 159-161
• Marsh GM, Youk AO, Morfeld P (2007) Mis-specified and non-robust mortality risk models for nasopharyngeal cancer in the National Cancer Institute formaldehyde worker cohort study. Reg. Toxicol. Pharmacol. 47: 59-67.
• Marsh GM, Youk AO, Morfeld P, Collins JJ, Symons JM (2010) Incomplete follow-up in the National Cancer Institute's formaldehyde worker study and the impact on subsequent reanalyses and causal evaluations. Reg. Toxicol. Pharmacol. 58:233-236.
• Mueller JU, Bruckner T, Triebig G (2011) Exposure study to examine chemosensory effects of formaldehyde in hypersensitive and hyposensitive men. Manuscript under preparation
• Neuss S, Speit G (2008) Further characterization of the genotoxicity of formaldehyde in vitro by the sister chromatid exchange test and co-cultivation experiments. Mutagenesis 23: 355-357
• Neuss S, Moepps B, Speit G (2010a) Exposure of human nasal epithelial cells to formaldehyde does not lead to DNA damage in lymphocytes after co-cultivation. Mutagenesis 25: 359-364
• Neuss S, Zeller J, Ma-Hock L, Speit G, (2010b) Inhalation of formaldehyde does not induce genotoxic effects in broncho-alveolar lavage (BAL) cells of rats. Mutat. Res. 695: 61-68
• Neuss S, Holzmann K, Speit G (2010c) Gene expression changes in primary human nasal epithelial cells exposed to formaldehyde in vitro. Toxicol. Letters 198: 289-295
• Riess U, Tegtbur U, Fauck C, Fuhrmann F, Markewitz D, Salthammer T (2010) Experimental setup and analytical methods for the non-invasive determination of volatile organic compounds, formaldehyde and NOx in exhaled human breath. Analytica Chim. Acta 669: 53-62
• Salthammer T, Mentese S, Marutzky R (2010) Formaldehyde in the indoor environment. Chem. Rev. 110: 2536-2572
• Schmid O, Speit G (2007) Genotoxic effects induced by formaldehyde in human blood and implications for the interpretation of biomonitoring studies. Mutagenesis 22: 69-74
• Schripp T, Fauck C, Salthammer T (2010) Interferences in the determination of formaldehyde via PTR-MS: What do we learn from m/z 31?. Int. J. Mass Spectrometry 289: 170-172
• Speit G, Schmid O (2006) Local genotoxic effects of formaldehyde in humans measured by the micronucleus test with exfoliated epithelial cells. Mutat. Res. 613: 1-9
• Speit G, Schütz P, Högel J, Schmid O (2007) Characterization of the genotoxic potential of formaldehyde in V79 cells. Mutagenesis 22: 387-394
• Speit G, Schmid O, Fröhler-Keller M, Lang I, Triebig G (2007a) Assessment of local genotoxic effects of formaldehyde in humans measured by the micronucleus test with exfoliated buccal mucosa cells. Mutat. Res. 627: 129-135
• Speit G, Schmid O, Neuss S, Schütz P (2008) Genotoxic effects of formaldehyde in the human lung cell line A549 and in primary human nasal epithelial cells. Environ. Mol. Mutagen. 49: 300-307
• Speit G, Zeller J, Schmid O, Elhajouji A, Ma-Hock L, Neuss S (2009) Inhalation of formaldehyde does not induce systemic genotoxic effects in rats. Mutat. Res. 677: 76-85
• Speit G, Gelbke H-P, Pallapies D, Morfeld P (2010) Occupational exposure to formaldehyde, hematotoxicity and leukemia-specific chromosome changes in cultured myeloid progenitor cells - Letter to the Editor – Cancer Epidemiol. Biomarkers Prev. 19: 1882-1885
• Speit G, Schütz P, Weber I, Ma-Hock L, Kaufmann W, Gelbke HP, Durrer S (2011) Analysis of micronuclei, histopathological changes and cell proliferation in nasal epithelium cells of rats after exposure to formaldehyde by inhalation. Mutat. Res. 721: 127-135
• Speit G, Zeller J, Riegert C, Just W (2011a) Genetic polymorphisms in the formaldehyde dehydrogenase gene and their biological significance. (submitted for publication)
• Speit G, Kuehner S, Linsenmeyer R, Schuetz P (2011b) Does formaldehyde induce aneuploidy? Mutagenesis (accepted for publication)
• Zeller J, Ulrich A, Mueller JU, Riegert C, Neuss S, Bruckner T, Triebig G, Speit G (2011) Is individual nasal sensitivity related to cellular metabolism of formaldehyde and susceptibility towards formaldehyde-induced genotoxicity?. Mutation Res. 723: 11-17 (Study sponsored by EPF/VHI/FormaCare)
• Zeller J, Neuss S, Kühner S, Holzmann K, Högel J, Klingmann C, Müller J, Triebig G, Speit G (2011a) Assessment of genotoxic effects and changes in gene expression in humans exposed to formaldehyde by inhalation under controlled conditions. Mutagenesis 26: 555-61 (Study sponsored by EPF/VHI/FormaCare)